Phenotypes Associated with This Genotype

Genotype
MGI:3711341

• Allelic Composition: Lgr4^{Gt(pU-21)1Kymm}/Lgr4^{Gt(pU-21)1Kymm}
• Genetic Background: CBA.Cg-Lgr4^{Gt(pU-21)1Kymm}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:121125 )

• Background Sensitivity: 40% of mice die on a CBA/N background

reproductive system

abnormal reproductive system morphology ( J:121125 )

abnormal testis morphology ( J:121125 )

♂ • rete testis dilation, luminal swelling, and atrophy of the germinal epithelium of the seminiferous tubules

dilated rete testis ( J:121125 )

♂ • rete testis is dilated due to a water reabsorption failure

abnormal seminiferous tubule epithelium morphology ( J:121125 )

♂ • the germinal epithelium is atrophied

increased testis weight ( J:121125 )

♂ • slightly increased

abnormal sperm number ( J:121125 )

♂ • decreased sperm viability

abnormal epididymis morphology ( J:121125 )

♂ • contains short and dilated tubules with uneven sperm distribution

♂ • epithelial cells show less endocytosis and few secretion components basal cells detach from adjacent epithelial cells

♂ • some macrophage-like cells, which have amoebic cell membranes and lysosomal granules, are present on the basal side

♂ • the basement membranes are multilaminated and distorted

♂ • ECM-like material accumulates towards the mesenchymal cell layer

abnormal caput epididymis morphology ( J:121125 )

♂ • some regions lack sperm

decreased epididymis weight ( J:121125 )

♂

abnormal reproductive system physiology ( J:121125 )

asthenozoospermia ( J:121125 )

♂ • sperm are either immotile or have reduced motility

reduced female fertility ( J:121125 )

♀ • pregnancy rates are reduced when females are mated to wild-type males

♀ • however, pups that are conceived are sired and nurse normally

male infertility ( J:121125 )

♂

endocrine/exocrine glands

abnormal testis morphology ( J:121125 )

♂ • rete testis dilation, luminal swelling, and atrophy of the germinal epithelium of the seminiferous tubules

dilated rete testis ( J:121125 )

♂ • rete testis is dilated due to a water reabsorption failure

abnormal seminiferous tubule epithelium morphology ( J:121125 )

♂ • the germinal epithelium is atrophied

increased testis weight ( J:121125 )

♂ • slightly increased

growth/size/body

postnatal growth retardation ( J:121125 )

• all surviving mice have growth retardation

cellular

asthenozoospermia ( J:121125 )

♂ • sperm are either immotile or have reduced motility