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Phenotypes Associated with This Genotype
Genotype
MGI:3711335
Allelic
Composition		 Hey2tm1Eno/Hey2tm2Eno
Tg(Tagln-cre)1Her/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey2tm1Eno mutation (1 available); any Hey2 mutation (29 available)
Hey2tm2Eno mutation (0 available); any Hey2 mutation (29 available)
Tg(Tagln-cre)1Her mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:121577 )
• mice display partial perinatal lethality

cardiovascular system
ventricular septal defect ( J:121577 )
• VSDs are observed
decreased cardiac muscle contractility ( J:121577 )
• contractile dysfunction observed

muscle
decreased cardiac muscle contractility ( J:121577 )
• contractile dysfunction observed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory