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Phenotypes Associated with This Genotype
Genotype
MGI:3711109
Allelic
Composition
B2mtm1Unc/B2mtm1Unc
Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic
Background
NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (37 available); any B2m mutation (52 available)
Tg(HLA-A/H2-D/B2M)1Dvs mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
• HLA-A2.1-restricted T cells from mice as young as 5 weeks of age respond to IGRP (islet-specific glucose-6-phophatase catalytic subunit-related protein) peptides
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets
• 55% of females develop type I diabetes by 30 weeks of age, with significantly accelerated onset compared with non transgenic littermates

hematopoietic system
• CD8+ T cells develop, but at significantly reduced numbers (~10%) compared to NOD controls
• islet-infiltrating T cells show different patterns of recognition to various IGRP peptides; peptide 228-236 is immunodominant HLA-A2.1-binding epitope of IGRP in 12-13 week old nondiabetic female mice
• T cells from islets show HLA-A2-restricted cytotoxicity against human HLA-A2.1-positive human pancreatic islets, as well as mouse islets

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:121685


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory