Analysis Tools
immune system
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• homing is 45% and 65% of wild-type mice in 2-hour and 20-hour assays, respectively, and is not inhibited by MECA-79 unlike in wild-type mice
• after challenge with dinitrofluorobenzene homing of lymphocytes to draining lymph nodes and lymphocyte numbers are reduced by 37% compared to wild-type mice
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• rolling velocities of T lymphocytes in venules (orders III and IV) are increased about 3-fold
• the percentage of cells rolling and sticking is decreased
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• more severe decrease in the number of lymph-node resident B cells compared to single homozygotes
• however, no change is detected in the total number of lymphocytes found in secondary lymphoid tissues
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• when sensitized and challenged with dinitrofluorobenzee (DNFB) mice exhibit 37% less ear swelling and have less CD3+ T lymphocyte infiltration than wild-type mice
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cellular
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• homing is 45% and 65% of wild-type mice in 2-hour and 20-hour assays, respectively, and is not inhibited by MECA-79 unlike in wild-type mice
• after challenge with dinitrofluorobenzene homing of lymphocytes to draining lymph nodes and lymphocyte numbers are reduced by 37% compared to wild-type mice
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• rolling velocities of T lymphocytes in venules (orders III and IV) are increased about 3-fold
• the percentage of cells rolling and sticking is decreased
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hematopoietic system
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• homing is 45% and 65% of wild-type mice in 2-hour and 20-hour assays, respectively, and is not inhibited by MECA-79 unlike in wild-type mice
• after challenge with dinitrofluorobenzene homing of lymphocytes to draining lymph nodes and lymphocyte numbers are reduced by 37% compared to wild-type mice
|
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• rolling velocities of T lymphocytes in venules (orders III and IV) are increased about 3-fold
• the percentage of cells rolling and sticking is decreased
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