Phenotypes Associated with This Genotype

Genotype
MGI:3711067

• Allelic Composition: B4gat1^tm1Mifu/B4gat1^tm1Mifu
• Genetic Background: B6.Cg-B4gat1^tm1Mifu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:120722 )

N • dinitrofluorobenzene-induced contact hypersensitivity is similar to wild-type mice unlike in mice double homozygous for this allele and Gcnt1^tm1Jxm

impaired leukocyte tethering or rolling ( J:120722 )

• increase in rolling velocities and reduction in sticking of B and T cells

• increase in rolling and reduction in sticking is more severe in B cells than in T cells

abnormal lymph node cell ratio ( J:120722 )

• fewer B lymphocytes are found in the lymph node and this is accompa nied by an increase in the number of T cells present

• however, the total number of lymphocytes in secondary lymphoid organs is similar to wild-type

cellular

impaired leukocyte tethering or rolling ( J:120722 )

• increase in rolling velocities and reduction in sticking of B and T cells

• increase in rolling and reduction in sticking is more severe in B cells than in T cells

hematopoietic system

impaired leukocyte tethering or rolling ( J:120722 )

• increase in rolling velocities and reduction in sticking of B and T cells

• increase in rolling and reduction in sticking is more severe in B cells than in T cells