Mouse Genome Informatics
cn
    Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• about 8% of mice die by 2 months of age

tumorigenesis
• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors
• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)
• myxoid and fibrous changes are observed

growth/size
• about 8% of mice are born small

Mouse Models of Human Disease
OMIM IDRef(s)
Sarcoma, Synovial 300813 J:120967