Phenotypes Associated with This Genotype

Genotype
MGI:3710974

• Allelic Composition: Tg(APOC3)2721Bres/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:81184 )

• the plasma lipoprotein profile of heterozygous G1 transgenic mice reveals a decrease in high-density lipoprotein (HDL) concomitant with a decrease in the plasma concentration of mouse APOA1 protein

increased circulating triglyceride level ( J:81184 )

• fasting plasma from transgenic mice has a milky appearance characteristic of severe hypertriglyceridemia (HTG) in humans

• the average plasma triglyceride concentration among 6 G1 transgenic mice was 959 +/- 217 mg/dl; one animal had a concentration of 1488 mg/dl, while for control mice the average was 40 mg/dl

• a linear correlation (slope 1.14) was found between the concentration of human APOC3 in plasma of individual mice and the animals' plasma triglyceride levels

increased circulating VLDL triglyceride level ( J:81184 )

• the plasma lipoprotein profile of heterozygous G1 transgenic mice reveals a predominance of particles the size of very low density lipoproteins (VLDL)