Analysis Tools
skeleton
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• at P30, failure of fusion in the dorsal vertebrae
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• at P10, the growth plate has altered columnar organization and is discontinuous across the width of the skeletal elements with continuous primary and secondary ossification centers in areas where the growth plate is missing
• at P15, growth plate structure is completely abrogated with ossification centers merged and the distance from the articular surface to the trabecular bone is reduced
• at P30, growth plates in the long bones are missing
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• at P7, the length of the zone of flat proliferating cells is reduced
• at P7 and P10 fewer cells are undergoing mitosis (pH3+) in the growth plate (86% and 78%, respectively)
• at P10, columnar alignment of the proliferating cells is lost with abnormal movement of the cells during rotation despite intact polarity of the cells
• at P15, no mitosis is detected, cells have a round morphology and lack polarity
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• at P15, hypertrophic cells invade the prehypertrophic zones
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• at P7, reduction of the epiphysis is due to reduction in the flat chondrocyte regions without a reduction in the length of the hypertrophic zone
• at P10, the length is reduced; however, the width is increased
• at P30, the growth plates in the long bones are missing
• however, the length of long bones and the levels of ossification are no different than in wild-type mice at E18.5 and P0
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• at P30, ribs are small and deformed
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• sporadic at P30
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• at E15.5, P0 and P7, 80% reduction in the number of chondrocytes with cilia
• however, perichondrial cells have cilia
• at P10, the actin cytoskeleton in chondrocytes is disorganized
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nervous system
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• at P30, failure of fusion in the dorsal vertebrae
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growth/size/body
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• at P30, dwarfism occurs in which there is a 32% reduction in crown to rump and limb length
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embryo
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• at P30, failure of fusion in the dorsal vertebrae
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cellular
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• at P10, the actin cytoskeleton in chondrocytes is disorganized
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