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Phenotypes Associated with This Genotype
Genotype
MGI:3710766
Allelic
Composition
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at 24 months
• only occur in forebrain after 6 months of age, and no cerebellar deposits are routinely observed (J:101023)
• at 2 years (J:121703)
• at 24 months, mice develop amyloid plaques in the cerebral cortex and hippocampus unlike wild-type mice (J:159623)
• at 24 months

cardiovascular system
• after myocardin gene transfer to neocortical pial vessels in 16-month old mice, mice show significant reduction in cerebral blood flow response to whisker stimulation

hematopoietic system
• at 24 months

immune system
• at 24 months

homeostasis/metabolism
• formic acid extractable Abeta40 and Abeta42 levels are dramatically elevated at 14.5 months compared to Tg(Prnp-ITM2B/APP695*42)A12Emcg mice
• only occur in forebrain after 6 months of age, and no cerebellar deposits are routinely observed (J:101023)
• at 2 years (J:121703)
• at 24 months, mice develop amyloid plaques in the cerebral cortex and hippocampus unlike wild-type mice (J:159623)

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:119251


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory