Mouse Genome Informatics
tg
    Tg(APPSWE)2576Kha/0
involves: C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
nervous system
• at 24 months
• only occur in forebrain after 6 months of age, and no cerebellar deposits are routinely observed (J:101023)
• at 2 years (J:121703)
• at 24 months, mice develop amyloid plaques in the cerebral cortex and hippocampus unlike wild-type mice (J:159623)
• at 24 months

cardiovascular system
• after myocardin gene transfer to neocortical pial vessels in 16-month old mice, mice show significant reduction in cerebral blood flow response to whisker stimulation

hematopoietic system
• at 24 months

immune system
• at 24 months

homeostasis/metabolism
• formic acid extractable Abeta40 and Abeta42 levels are dramatically elevated at 14.5 months compared to Tg(Prnp-ITM2B/APP695*42)A12Emcg mice
• only occur in forebrain after 6 months of age, and no cerebellar deposits are routinely observed (J:101023)
• at 2 years (J:121703)
• at 24 months, mice develop amyloid plaques in the cerebral cortex and hippocampus unlike wild-type mice (J:159623)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:119251