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Phenotypes Associated with This Genotype
Genotype
MGI:3710763
Allelic
Composition
Tg(Prnp-ITM2B/APP695*42)A12Emcg/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B/APP695*42)A12Emcg mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• cored plaques can be observed as early as 3 months in molecular layer of cerebella of transgenic mice and becoming more pronounced with age; occasional extracellular plaques are seen in the entorhinal/piriform cortices and hippocampus at 6 months of age, but aren't consistently found until >12 months of age
• oldest mice show widespread pathology with cored and diffuse plaques in cerebellum, cortex, hippocampus, and olfactory bulb
• extracellular amyloid plaques show dense amyloid cores with radiating fibrils; many bundles of dystrophic neurites are observed at the periphery of these plaques
• compact plaques range from 38 um in diameter at 3 months to 58 um at 1-18 months
• tau pathology is not evident
• endogenous mouse Abeta is detected in some cored plaques and in diffuse deposits in older mice
• forebrain pathology only consistently develops after 12 months of age
• reactive gliosis is associated with plaques

homeostasis/metabolism
• Abeta1-42 peptide levels in 3-month old transgenic brains are ~1- to 1.5-fold higher than levels in 3- and 6-month oldTg(APPSWE)2576Kahs controls
• cored plaques can be observed as early as 3 months in molecular layer of cerebella of transgenic mice and becoming more pronounced with age; occasional extracellular plaques are seen in the entorhinal/piriform cortices and hippocampus at 6 months of age, but aren't consistently found until >12 months of age
• oldest mice show widespread pathology with cored and diffuse plaques in cerebellum, cortex, hippocampus, and olfactory bulb
• extracellular amyloid plaques show dense amyloid cores with radiating fibrils; many bundles of dystrophic neurites are observed at the periphery of these plaques
• compact plaques range from 38 um in diameter at 3 months to 58 um at 1-18 months
• tau pathology is not evident
• endogenous mouse Abeta is detected in some cored plaques and in diffuse deposits in older mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:101023


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory