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Phenotypes Associated with This Genotype
Genotype
MGI:3710761
Allelic
Composition
Tg(Prnp-ITM2B/APP695*40)1Emcg/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B/APP695*40)1Emcg mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice do not show Abeta deposits or amyloid plaque formation

homeostasis/metabolism
• Abeta1-40 peptide levels in 3 month old transgenic brains are ~2- to 3-fold higher than levels in Tg(APPSWE)2576Kahs controls (80-120 pm/g vs ~40 pm/g)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:101023


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory