Phenotypes Associated with This Genotype

Genotype
MGI:3710690

• Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako
• Genetic Background: involves: 129S1/Sv * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased myocardial fiber size ( J:57380 )

• smaller myocyte size

increased myocardial fiber number ( J:57380 )

• 2-3-fold increase in the total number of cardiac myocytes

enlarged heart ( J:57380 )

• hearts are increased in size from 2 days of age onward

increased heart weight ( J:57380 )

• by 21 days of age, the wet weight of hearts are increased by more than 40%

heart hyperplasia ( J:57380 )

• prolonged duration of cardiac myocyte hyperplasia

abnormal fetal cardiomyocyte proliferation ( J:57380 )

• percentage of neonatal myocytes in S phase is increased, concomitant with a decrease in the percentage of G0/G1 cells, indicating prolonged proliferation of cardiac myocytes

muscle

decreased myocardial fiber size ( J:57380 )

• smaller myocyte size

increased myocardial fiber number ( J:57380 )

• 2-3-fold increase in the total number of cardiac myocytes

abnormal fetal cardiomyocyte proliferation ( J:57380 )

• percentage of neonatal myocytes in S phase is increased, concomitant with a decrease in the percentage of G0/G1 cells, indicating prolonged proliferation of cardiac myocytes

cellular

abnormal fetal cardiomyocyte proliferation ( J:57380 )

• percentage of neonatal myocytes in S phase is increased, concomitant with a decrease in the percentage of G0/G1 cells, indicating prolonged proliferation of cardiac myocytes

growth/size/body

enlarged heart ( J:57380 )

• hearts are increased in size from 2 days of age onward

increased heart weight ( J:57380 )

• by 21 days of age, the wet weight of hearts are increased by more than 40%

heart hyperplasia ( J:57380 )

• prolonged duration of cardiac myocyte hyperplasia