Phenotypes for Adamts5 Tg(CMV-cre)1Cgn MGI:3710666 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Adamts5^tm1Lex/Adamts5^tm1.1Lex Tg(CMV-cre)1Cgn/?
Genetic Background	involves: 129S5/SvEvBrd * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5^tm1.1Lex mutation (0 available); any Adamts5 mutation (54 available)
Adamts5^tm1Lex mutation (2 available); any Adamts5 mutation (54 available)
Tg(CMV-cre)1Cgn mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:105138 )

N	• mice are fertile

skeleton

abnormal cartilage morphology ( J:105138 )

• aggrecan loss (as measured by loss of toiludine blue staining in the tibiofemoral joint) is significantly less (1.15+/-0.15 mean score compared to 1.94+/-0.13 in wild-type joints)

• tibial cartilage erosion is seen in 1 of 13 joints as compared to 5 of 14 wild-type joints

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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