Phenotypes for Spen Tg(Camk2a-cre)10Kmik MGI:3710558 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Spen^tm2.1Hon/Spen^tm2.1Hon Tg(Camk2a-cre)10Kmik/?
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spen^tm2.1Hon mutation (3 available); any Spen mutation (136 available)
Tg(Camk2a-cre)10Kmik mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain size ( J:121523 )

• brain hypoplasia by 8 weeks of age

behavior/neurological

abnormal learning/memory/conditioning ( J:121523 )

• reduced freezing response to foot shock during training

abnormal contextual conditioning behavior ( J:121523 )

• reduced freezing response

abnormal cued conditioning behavior ( J:121523 )

• reduced freezing response

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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