Phenotypes Associated with This Genotype

Genotype
MGI:3710557

• Allelic Composition: Spen^tm2.1Hon/Spen^tm2.1Hon; Tg(Nes-cre)1Kag/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:121523 )

• increased mortality before 10 weeks of age

growth/size/body

postnatal growth retardation ( J:121523 )

• although normal at birth, mice are growth retarded at 3 weeks of age

nervous system

decreased brain weight ( J:121523 )

abnormal telencephalon morphology ( J:121523 )

enlarged lateral ventricles ( J:121523 )

small hippocampus ( J:121523 )

• reduced in size

thin cerebral cortex ( J:121523 )

• severe reductions in the thickness of the cerebral cortex