Phenotypes Associated with This Genotype

Genotype
MGI:3710499

• Allelic Composition: Tg(Myh6-Ccna2)58Djw/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:92551 )

• at 6 months of age, the number of ventricular myocytes is increased on average 67.3%

• hearts exhibit an increase in cardiomyocyte DNA synthesis starting at P2, with most cardiomyocytes being mononuclear at P7

decreased myocardial fiber size ( J:92551 )

• myocyte cross-sectional areas are slightly reduced and myocyte length is shorter

enlarged heart ( J:92551 )

• hearts occupy an average of 41% of the chest area compared with 30.5% by the controls, indicating enlargement

increased heart weight ( J:92551 )

• heart weight to body weight ratio of adults is significantly increased beginning at 6 months of age

heart hyperplasia ( J:92551 )

• cardiomyocyte hyperplasia due to an increase in postnatal mitosis

decreased cardiac muscle contractility ( J:92551 )

• mild, but significant, decrease in ejection fraction and fractional shortening in hearts at 8 months of age, but not at 3 months of age

muscle

abnormal myocardial fiber morphology ( J:92551 )

• at 6 months of age, the number of ventricular myocytes is increased on average 67.3%

• hearts exhibit an increase in cardiomyocyte DNA synthesis starting at P2, with most cardiomyocytes being mononuclear at P7

decreased myocardial fiber size ( J:92551 )

• myocyte cross-sectional areas are slightly reduced and myocyte length is shorter

decreased cardiac muscle contractility ( J:92551 )

• mild, but significant, decrease in ejection fraction and fractional shortening in hearts at 8 months of age, but not at 3 months of age

growth/size/body

enlarged heart ( J:92551 )

• hearts occupy an average of 41% of the chest area compared with 30.5% by the controls, indicating enlargement

increased heart weight ( J:92551 )

• heart weight to body weight ratio of adults is significantly increased beginning at 6 months of age

heart hyperplasia ( J:92551 )

• cardiomyocyte hyperplasia due to an increase in postnatal mitosis