Phenotypes Associated with This Genotype

Genotype
MGI:3710408

• Allelic Composition: Tg(Myh6-Ccnd1)#Ljf/0
• Genetic Background: involves: C3HeB/FeJ * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:40920 )

• approximately 2-fold increase in the total number of cardiomyocytes in 14-day old mutants

• adult cardiomyocytes exhibit abnormal patterns of multinucleation, with an increase in the number of nuclei

increased heart weight ( J:40920 , J:104622 )

• 40% increase in the heart weight to body weight ratio (J:40920)

abnormal myocardial fiber physiology ( J:40920 , J:104622 )

• tritiated thymidine incorporation analysis shows sustained cardiomyocyte DNA synthesis in adults (J:40920)

• myocardial injury (isoproterenol-induced hypertrophy and cautery damage) reduces the ventricular cardiomyocyte DNA synthesis that is observed in mutants (J:104622)

muscle

abnormal myocardial fiber morphology ( J:40920 )

• approximately 2-fold increase in the total number of cardiomyocytes in 14-day old mutants

• adult cardiomyocytes exhibit abnormal patterns of multinucleation, with an increase in the number of nuclei

growth/size/body

increased heart weight ( J:40920 , J:104622 )

• 40% increase in the heart weight to body weight ratio (J:40920)