Phenotypes Associated with This Genotype

Genotype
MGI:3710383

• Allelic Composition: Tsg101^tm1Kuw/Tsg101^tm1Kuw; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:121475 )

♀ • conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene

♀ • some regions of the mammary gland are severely underdeveloped

♀ • terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation

♀ • a subset of females, where recombination was inefficient are able to lactate

integument

abnormal mammary gland growth during lactation ( J:121475 )

♀ • conditional knockout mice display a variable degree of phenotypic abnormalities in the postpartum mammary glands, resulting from mosaic expression pattern of the cre transgene

♀ • some regions of the mammary gland are severely underdeveloped

♀ • terminal ducts and alveolar structures in mammary gland exhibit a mosaic phenotype as reported at day 10 of lactation

♀ • a subset of females, where recombination was inefficient are able to lactate