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Phenotypes Associated with This Genotype
Genotype
MGI:3710367
Allelic
Composition		 Braftm1(ARAF)Urr/Braftm1(ARAF)Urr
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1(ARAF)Urr mutation (0 available); any Braf mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:112971 )
• Background Sensitivity: while embryos survive passed E12.5 in a B6 background, less than one third of mice survive passed E13.5

cellular
increased apoptosis ( J:112971 )
• endothelial cells undergo increased apoptosis compared to controls or Braftm1(ARAF)Urr homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory