Phenotypes Associated with This Genotype

Genotype
MGI:3710366

• Allelic Composition: Braf^tm1Zim/Braf^tm1Zim
• Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:112971 )

• embryos do not survive past E12.5

nervous system

abnormal telencephalon development ( J:112971 )

• at E10.5, and more profoundly at E12.5, the cortical neurons (TBB1+) in the preplate layer are reduced twofold, disorganized and dispersed in the cortex

• at E10.5 and E12.5, the number of metaphase cells (pH3+) is increased and more ectopic cells are found

• at E10.5 and E12.5, many apoptotic cells (CASP3+) are found in the central part of the sagittal sections including some neurons (TBB1+) unlike controls in which no apoptosis is observed

• at E12.5, there is a 2-fold reduction in cortical neurons (TBB1+) and slight reduction in proliferation with proliferating cells confined to the basal half of the ventricular zone