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Phenotypes Associated with This Genotype
Genotype
MGI:3710360
Allelic
Composition
Smad5tm1Huy/Smad5tm1.1Huy
Tg(Tagln-cre)1Her/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad5tm1.1Huy mutation (0 available); any Smad5 mutation (26 available)
Smad5tm1Huy mutation (0 available); any Smad5 mutation (26 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mild dilation of the heart
• no cardiomyopathy, cardiac hypertrophy, or differences in heart rate and have normal blood vessel development, blood vessel morphology in adults, angiogenesis and vascular remodeling response
• at 9 months of age, females, but not males, show larger systolic and diastolic LV internal diameters and decreased fractional shortening, indicating decreased cardiac contractility

homeostasis/metabolism
• females, but not males, perform worse in a treadmill experiment

muscle
• at 9 months of age, females, but not males, show larger systolic and diastolic LV internal diameters and decreased fractional shortening, indicating decreased cardiac contractility

behavior/neurological
• females, but not males, perform worse in a treadmill experiment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/20/2026
MGI 6.24
The Jackson Laboratory