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Phenotypes Associated with This Genotype
Genotype
MGI:3710355
Allelic
Composition
Brca1tm1Aash/Brca1tm1Aash
Tg(LGB-cre)74Acl/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm1Aash mutation (3 available); any Brca1 mutation (82 available)
Tg(LGB-cre)74Acl mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors

endocrine/exocrine glands
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors
• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

integument
• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

neoplasm
• some mice (which have not gone through pregnancies) develop salivary gland myoepithelial tumors
• mammary tumors occur in these control mice at lower frequency (12%: 5/43 animals) and much longer latency (12-15 months) compared to mice on a Trp43-haploinsufficient background

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
OMIM:600048
OMIM:605365
J:119996


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory