Analysis Tools
neoplasm
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• some (2/59) develop salivary gland malignant myoepithelial tumors
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• mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands
• tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body
• majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32)
• most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate
• most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation
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• high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumors
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endocrine/exocrine glands
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• some (2/59) develop salivary gland malignant myoepithelial tumors
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 |
• only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells
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• mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands
• tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body
• majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32)
• most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate
• most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation
|
|
• high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumors
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integument
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• only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells
|
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• mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands
• tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body
• majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32)
• most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate
• most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation
|
|
• high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumors
|
digestive/alimentary system
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• some (2/59) develop salivary gland malignant myoepithelial tumors
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growth/size/body
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• some (2/59) develop salivary gland malignant myoepithelial tumors
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craniofacial
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• some (2/59) develop salivary gland malignant myoepithelial tumors
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