Phenotypes Associated with This Genotype

Genotype
MGI:3710351

• Allelic Composition: Xpc^tm1Ecf/Xpc^tm1Ecf
• Genetic Background: involves: 129 * SKH1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair follicle morphology ( J:120007 )

• cyclobutane pyrimidine dimers are observed in hair follicles after treatment with a total UV dose of 1.0 kJ/m²

epidermal hyperplasia ( J:120007 )

• basal cells exhibit hypoplasia after a total UV dose of 1.0 kJ/m² despite the dose being much below the minimal erythema dose

increased sensitivity to skin irradiation ( J:120007 )

• cyclobutane pyrimidine dimers are observed in cells within the dermis at a reduced level (4.7% compared to 12% in wild-type mice) after treatment with a total UV dose of 1.0 kJ/m²

• pyridine pirimidone photoproducts accumulate in about 1.8% of epidermal basal cells after treatment with a total UV dose of 1.0 kJ/m² and no increase in photoproducts with increased exposure