Analysis Tools
hematopoietic system
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• spleens are enlarged relative to controls (0.5% spleen weight to body weight vs. ~0.4% in controls)
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• erythroid progenitors from bone marrow form ~50% fewer erythroid burst-forming units (BFU-E) and colony-forming units (CFU-E) in culture than control cells, whereas erythroid progenitors from the spleen form more BFU-E and CFU-E
• there are fewer CD71+ immature erythroid progenitors in the bone marrow, and a higher percentage of CD71+ /Ter119+ double positive cells in the spleen
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• with acute deletion of Epas1 at 6-8 weeks induced by tamoxifen administration, animals have decreased red blood cell numbers relative to controls
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• with acute deletion of Epas1 at 6-8 weeks induced by tamoxifen administration, animals have decreased hematocrit relative to controls
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• with acute deletion of Epas1 at 6-8 weeks induced by tamoxifen administration, animals have decreased hemoglobin levels relative to controls
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• numbers are decreased compared to controls
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• mice show weak induction of erythropoietin after phenylhydrazine treatment
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immune system
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• spleens are enlarged relative to controls (0.5% spleen weight to body weight vs. ~0.4% in controls)
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growth/size/body
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• spleens are enlarged relative to controls (0.5% spleen weight to body weight vs. ~0.4% in controls)
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