Mouse Genome Informatics
cn
    Foxm1tm1Rhc/Foxm1tm1Rhc
Tg(Tek-cre)1Ywa/0

involves: 129X1/SvJ * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• approximately 20% die in late gestation-postnatally

cardiovascular system
N
• in the heart, no morphological defects are seen in the structure of coronary vessels and cardiac microcirculation, or in atrioventricular valves and the ventricular outflow tract and mutants have normal numbers of cardiomyocytes (J:119481)
• mutants that die exhibit vascular abnormalities in the lung

respiratory system
• mutants that die exhibit vascular abnormalities in the lung
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs

tumorigenesis
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls
• mutants exhibit increased numbers of lung adenomas and larger tumor diameters 30 weeks after initial urethane injection compared to controls

immune system
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs

homeostasis/metabolism
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls

Mouse Models of Human Disease
OMIM IDRef(s)
Lung Cancer 211980 J:167773