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Phenotypes Associated with This Genotype
Genotype
MGI:3710341
Allelic
Composition
Foxm1tm1Rhc/Foxm1tm1Rhc
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxm1tm1Rhc mutation (0 available); any Foxm1 mutation (7 available)
Tg(Tek-cre)1Ywa mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 20% die in late gestation-postnatally (J:119481)
• approximately 20% die in late gestation-postnatally (J:119481)

cardiovascular system
N
• in the heart, no morphological defects are seen in the structure of coronary vessels and cardiac microcirculation, or in atrioventricular valves and the ventricular outflow tract and mutants have normal numbers of cardiomyocytes (J:119481)
• in the heart, no morphological defects are seen in the structure of coronary vessels and cardiac microcirculation, or in atrioventricular valves and the ventricular outflow tract and mutants have normal numbers of cardiomyocytes (J:119481)
• mutants that die exhibit vascular abnormalities in the lung (J:119481)
• mutants that die exhibit vascular abnormalities in the lung (J:119481)

respiratory system
• mutants that die exhibit vascular abnormalities in the lung (J:119481)
• mutants that die exhibit vascular abnormalities in the lung (J:119481)
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs (J:167773)
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs (J:167773)

tumorigenesis
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls (J:167773)
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment (J:167773)
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls (J:167773)
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls (J:167773)
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment (J:167773)
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls (J:167773)
• mutants exhibit increased numbers of lung adenomas and larger tumor diameters 30 weeks after initial urethane injection compared to controls (J:167773)
• mutants exhibit increased numbers of lung adenomas and larger tumor diameters 30 weeks after initial urethane injection compared to controls (J:167773)

immune system
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs (J:167773)
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs (J:167773)

homeostasis/metabolism
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment (J:167773)
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls (J:167773)
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls (J:167773)
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls (J:167773)
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment (J:167773)
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls (J:167773)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:167773


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory