About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3710341
Allelic
Composition
Foxm1tm1Rhc/Foxm1tm1Rhc
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxm1tm1Rhc mutation (0 available); any Foxm1 mutation (13 available)
Tg(Tek-cre)1Ywa mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 20% die in late gestation-postnatally

cardiovascular system
N
• in the heart, no morphological defects are seen in the structure of coronary vessels and cardiac microcirculation, or in atrioventricular valves and the ventricular outflow tract and mutants have normal numbers of cardiomyocytes
• mutants that die exhibit vascular abnormalities in the lung

respiratory system
• mutants that die exhibit vascular abnormalities in the lung
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs
• mutants exhibit increased numbers of lung adenomas and larger tumor diameters 30 weeks after initial urethane injection compared to controls

neoplasm
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls
• mutants exhibit increased numbers of lung adenomas and larger tumor diameters 30 weeks after initial urethane injection compared to controls

immune system
• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs

homeostasis/metabolism
• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls
• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment
• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:167773


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory