Phenotypes Associated with This Genotype

Genotype
MGI:3710341

• Allelic Composition: Foxm1^tm1Rhc/Foxm1^tm1Rhc; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:119481 )

• approximately 20% die in late gestation-postnatally

cardiovascular system

cardiovascular system phenotype ( J:119481 )

N • in the heart, no morphological defects are seen in the structure of coronary vessels and cardiac microcirculation, or in atrioventricular valves and the ventricular outflow tract and mutants have normal numbers of cardiomyocytes

abnormal lung vasculature morphology ( J:119481 )

• mutants that die exhibit vascular abnormalities in the lung

respiratory system

abnormal lung vasculature morphology ( J:119481 )

• mutants that die exhibit vascular abnormalities in the lung

lung inflammation ( J:167773 )

• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs

increased lung adenoma incidence ( J:167773 )

• mutants exhibit increased numbers of lung adenomas and larger tumor diameters 30 weeks after initial urethane injection compared to controls

neoplasm

increased incidence of tumors by chemical induction ( J:167773 )

• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls

• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment

• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls

increased lung adenoma incidence ( J:167773 )

• mutants exhibit increased numbers of lung adenomas and larger tumor diameters 30 weeks after initial urethane injection compared to controls

immune system

lung inflammation ( J:167773 )

• mutants treated with urethane exhibit chronic lung inflammation unlike control lungs

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:167773 )

• mutants exhibit increased numbers of lung tumors (adenomas) and larger tumor diameters 30 weeks after initial urethane injection compared to controls

• mutants exhibit increased lung tumorigenesis after MCA/BHT treatment

• tumors from mutants treated with urethane exhibit increased proliferation compared to tumors from controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:167773