Phenotypes Associated with This Genotype

Genotype
MGI:3710340

• Allelic Composition: Foxm1^tm1.1Rhc/Foxm1^tm1.1Rhc
• Genetic Background: B6.129X1-Foxm1^tm1.1Rhc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal ventricle myocardium morphology ( J:119481 )

• E13.5-18.5 hearts exhibit thinning of the ventricular myocardium

abnormal fetal cardiomyocyte morphology ( J:119481 )

• severe accumulation of polyploid cardiomyocytes is seen in E13.5-18.5 heart tissues, including ventricular myocardium, interventricular septum, atrium, and heart trabeculae

• increase in the size of cardiomyocyte nuclei is noted at E15.5 and E18.5

decreased fetal cardiomyocyte number ( J:119481 )

• reduced number of cardiomyocytes at E13.5 and E18.5

increased fetal cardiomyocyte size ( J:119481 )

• enlarged cardiomyocytes are seen in the atrium and ventricle as early as E9.5

small heart ( J:119481 )

• 25% reduction in heart size at E15.5 but not at E13.5

ventricular hypoplasia ( J:119481 )

thick heart valve cusps ( J:119481 )

• 1.3-fold increase in thickness of heart valve leaflets at E13.5

thick mitral valve cusps ( J:119481 )

• thickening of atrioventricular (A/V) valves (mitral valve leaflets) at E13.5

decreased heart left ventricle size ( J:119481 )

• hearts show a 43% reduction in the thickness of the left ventricle at E13.5 and a 57% reduction at E15.5

dilated heart ventricle ( J:119481 )

• embryos display dilated heart ventricles

decreased fetal cardiomyocyte proliferation ( J:119481 )

• developing cardiomyocytes show diminished DNA replication and mitosis at E15.5

cellular

decreased fetal cardiomyocyte proliferation ( J:119481 )

• developing cardiomyocytes show diminished DNA replication and mitosis at E15.5

muscle

abnormal ventricle myocardium morphology ( J:119481 )

• E13.5-18.5 hearts exhibit thinning of the ventricular myocardium

decreased fetal cardiomyocyte proliferation ( J:119481 )

• developing cardiomyocytes show diminished DNA replication and mitosis at E15.5