Phenotypes Associated with This Genotype

Genotype
MGI:3709738

• Allelic Composition: Crmp1^tm1.1Swl/Crmp1^tm1.1Swl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus pyramidal cell morphology ( J:120105 )

• MAP2+ CA1 pyramidal cells are shrunken but not due to abnormal Tau expression

• mice have fewer growth cones in the dendritic layer of CA1

• however, pyramidale and stratum oriens layers are normal

• dendrites and dendritic spine are poorly formed

• however, axon formation is normal

abnormal long-term potentiation ( J:120105 )

• mice are impaired in long term potentiation induction and maintenance

• however, paired pulse facilitation of field excitatory postsynaptic potentials are normal

behavior/neurological

abnormal spatial learning ( J:120105 )

• longer mean daily escape latencies even after training

• however, no visual or spontaneous locomotor activity deficits are observed

• mice spend less time in target quadrants and more time in non-target quadrants than control mice