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Phenotypes Associated with This Genotype
Genotype
MGI:3709555
Allelic
Composition
H2q/?
Ncf1m1J/Ncf1m1J
Genetic
Background
B6.Cg-Ncf1m1J H2q
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2q mutation (4 available); any H2 mutation (262 available)
Ncf1m1J mutation (3 available); any Ncf1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ncf1m1J/ Ncf1m1J mice carrying the H2q haplotype develop enhanced collagen II autoimmunity and chronic collagen II induced arthritis

immune system
• the delayed-type hypersensitivity response against collagen II, not but OVA, is elevated compared to wild-type
• MOG(79-96) peptide-induced EAE is milder in mutants than in wild-type
• MOG protein-induced EAE is more severe in mutants than in wild-type
• mutants exhibit increased susceptibility to collagen II induced arthritis, developing more severe arthritis and earlier onset than wild-type
• levels of antibodies directed against the injected collagen II antigen are higher, with a predominant increase in IgG
• many females develop severe arthritis during the first days after partus; arthritis is as severe and chronic as the collagen II induced arthritis
• females exhibit massive destruction of bone and cartilage in the ankle joint and have an elevated amount of antibodies against collagen II

skeleton
• mutants exhibit increased susceptibility to collagen II induced arthritis, developing more severe arthritis and earlier onset than wild-type
• levels of antibodies directed against the injected collagen II antigen are higher, with a predominant increase in IgG
• many females develop severe arthritis during the first days after partus; arthritis is as severe and chronic as the collagen II induced arthritis
• females exhibit massive destruction of bone and cartilage in the ankle joint and have an elevated amount of antibodies against collagen II

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:92437


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory