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Phenotypes Associated with This Genotype
Genotype
MGI:3709549
Allelic
Composition		 Mesp1/Mesp2tm1Ysa/Mesp1+
Mesp1/Mesp2tm1Ysa/Mesp2tm11Ysa
Genetic
Background		 involves: C57BL/6 * CBA * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2tm1Ysa mutation (2 available); any Mesp1 mutation (19 available)
Mesp1/Mesp2tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp2tm11Ysa mutation (0 available); any Mesp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebrae morphology ( J:119678 )
• caudal vertebra are malformed and a posterior expansion of defects is seen
vertebral fusion ( J:119678 )
• more severe fusion of vertebra than in mice containing Mesp2 disruptions pedicles are fused

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory