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Phenotypes Associated with This Genotype
Genotype
MGI:3709381
Allelic
Composition		 Btktm1Gsv/Y
Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Btktm1Gsv mutation (0 available); any Btk mutation (20 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:94768 )
N
• calcium signaling of splenic B cells is restored
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene
decreased B cell number ( J:120989 )
• restored B220+ cell numbers peripherally
absent B-1a cells ( J:120989 )
• deficiency of CD5+ B cells in the peritoneum remains
abnormal pre-B cell morphology ( J:120989 )
• differentiation is partially restored
decreased immunoglobulin level ( J:120989 )
• decreased lambda light chain usage

hematopoietic system
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene
decreased B cell number ( J:120989 )
• restored B220+ cell numbers peripherally
absent B-1a cells ( J:120989 )
• deficiency of CD5+ B cells in the peritoneum remains
abnormal pre-B cell morphology ( J:120989 )
• differentiation is partially restored
decreased immunoglobulin level ( J:120989 )
• decreased lambda light chain usage

cellular
decreased B cell apoptosis ( J:120989 )
• B cell apoptosis is reduced compared to similar mice lacking the transgene

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory