Phenotypes for Blnk Btk Tg(CD19-BTK*K430R)XK24Rwhe MGI:3709379 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Blnk^tm1Pjln/Blnk^tm1Pjln Btk^tm1Gsv/Y Tg(CD19-BTK*K430R)XK24Rwhe/?
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnk^tm1Pjln mutation (0 available); any Blnk mutation (76 available)
Btk^tm1Gsv mutation (0 available); any Btk mutation (20 available)
Tg(CD19-BTK*K430R)XK24Rwhe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:94768 )

• B cell development is partially restored, by about 4-7 fold

• some differentiation into mature B cells occurs

• recirculationg B cell population in the bone marrow is improved

decreased immunoglobulin level ( J:94768 )

decreased IgG3 level ( J:94768 )

• IgG3 levels remain severely reduced

decreased IgM level ( J:94768 )

• improved or restored

neoplasm

neoplasm ( J:94768 )

N	• tumor suppressor function is restored

hematopoietic system