Phenotypes Associated with This Genotype

Genotype
MGI:3709376

• Allelic Composition: Btk^tm1Gsv/Btk⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell number ( J:35769 )

♀ • decreased number of B220+ cells peripherally

decreased mature B cell number ( J:35769 )

♀ • reduced numbers of mature IgM-IgD+ B cells

absent B-1a cells ( J:35769 )

♀ • deficiency of CD5+ B cells in the peritoneum for B cells expressing both the mutant and the wild-type allele

hematopoietic system

decreased B cell number ( J:35769 )

♀ • decreased number of B220+ cells peripherally

decreased mature B cell number ( J:35769 )

♀ • reduced numbers of mature IgM-IgD+ B cells

absent B-1a cells ( J:35769 )

♀ • deficiency of CD5+ B cells in the peritoneum for B cells expressing both the mutant and the wild-type allele