Phenotypes Associated with This Genotype

Genotype
MGI:3709277

• Allelic Composition: Th^tm1Srt/Th^tm1Srt; Tyr^c/Tyr^c
• Genetic Background: involves: 129S2/SvPas * C57BL/6J * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:54692 )

• embryonic lethality, however time of lethality is not provided

• treatment of pregnant heterozygous females with L-Dopa, a catecholamine precursor compound, from E8.5 until birth, can rescue the embryonic lethality of homozygotes

homeostasis/metabolism

abnormal adrenaline level ( J:54692 )

• adrenal epinephrine levels are almost completely absent

decreased dopamine level ( J:54692 )

• brain dopamine levels are almost completely absent

abnormal noradrenaline level ( J:54692 )

• heart, skin, brain and adrenal norepinephrine levels are almost completely absent