About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3709154
Allelic
Composition
Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)18Dbo/0
Genetic
Background
involves: C3H/HeJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-APPSwInd)18Dbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• amyloid burden worsens in untreated animals between 6 and 9 months of age
• with 3 months of doxycyclin treatment beginning at 6 months of age, suppression of transgene synthesis and complete arrest of increase in amyloid pathology is observed compared to untreated mice; however, in these mice no sign of reduction in amyloid burden is observed
• mice produce transgenic APP protein at 10- to 30-fold over endogenous App levels
• sensitivity of transgene suppression by doxycycline is intermediate between mice of line 885 and line 102

homeostasis/metabolism
• amyloid burden worsens in untreated animals between 6 and 9 months of age
• with 3 months of doxycyclin treatment beginning at 6 months of age, suppression of transgene synthesis and complete arrest of increase in amyloid pathology is observed compared to untreated mice; however, in these mice no sign of reduction in amyloid burden is observed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 OMIM:104300
OMIM:502500
OMIM:604154
OMIM:608907
J:109829


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/16/2017
MGI 6.09
The Jackson Laboratory