Phenotypes Associated with This Genotype

Genotype
MGI:3708939

• Allelic Composition: Grin1^tm1Rsp/Grin1^tm1Rsp; Tg(Camk2a-tTA)1Mmay/?; Tg(tetO-cre)LC1Bjd/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal long-term potentiation ( J:119834 )

• complete loss of NMDAR-mediated long term potential at dentate gyrus synapses

• however, long term potentiation at Schaffer collateral-CA1 synapses is similar to wild-type mice despite residual Cre activity in CA1 pyramidal cells

behavior/neurological

abnormal spatial working memory ( J:119834 )

• mice exhibit impaired spatial working memory but normal spatial reference memory in a 3 from 6 radial arm maze task