Phenotypes Associated with This Genotype

Genotype
MGI:3707983

• Allelic Composition: Atoh7^tm1Gan/Atoh7^tm2Gan
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:67382 )

• at E15.5, the ganglion cell layer contains very few differentiated ganglion cells

• however, at E11 and E15.5 the number of progenitor retinal ganglion cells are similar to that in heterozygotes and there is no evidence of increased apoptosis at E12.5 to E19

abnormal retina nerve fiber layer morphology ( J:67382 )

• absence of nerve fiber layer

nervous system

abnormal retina ganglion cell morphology ( J:67382 )

• at E15.5, the ganglion cell layer contains very few differentiated ganglion cells

• however, at E11 and E15.5 the number of progenitor retinal ganglion cells are similar to that in heterozygotes and there is no evidence of increased apoptosis at E12.5 to E19