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Phenotypes Associated with This Genotype
Genotype
MGI:3707957
Allelic
Composition		 Foxp3tm3Tch/Foxp3+
Genetic
Background		 C.129X1-Foxp3tm3Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm3Tch mutation (1 available); any Foxp3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:120636 )
N
• females develop and live normally, and are free of lymphoproliferative disease

immune system
increased T cell apoptosis ( J:120636 )
• mice have a 4-fold increase in numbers of late apoptotic cells among EGFP+ CD4+ single positive thymocytes relative to controls
• EGFP+ T cells show more apoptosis than EGFP- T cells from the same mouse, or EGFP+ and EGFP-T cells from controls
decreased T cell number ( J:120636 )
• peripheral lymphoid tissues of females have fewer EGFP+ T cells than controls
decreased thymocyte number ( J:120636 )
• females have a lower percentage of EGFP+ CD4+ single positive thymocytes in the periphery compared to controls
abnormal CD4-positive, alpha-beta T cell physiology ( J:120636 )
• in response to stimulation, EGFP+ CD4+ T cells show substantial proliferation whereas cells from Foxp3tm2Tch females do not proliferate

hematopoietic system
increased T cell apoptosis ( J:120636 )
• mice have a 4-fold increase in numbers of late apoptotic cells among EGFP+ CD4+ single positive thymocytes relative to controls
• EGFP+ T cells show more apoptosis than EGFP- T cells from the same mouse, or EGFP+ and EGFP-T cells from controls
decreased T cell number ( J:120636 )
• peripheral lymphoid tissues of females have fewer EGFP+ T cells than controls
decreased thymocyte number ( J:120636 )
• females have a lower percentage of EGFP+ CD4+ single positive thymocytes in the periphery compared to controls
abnormal CD4-positive, alpha-beta T cell physiology ( J:120636 )
• in response to stimulation, EGFP+ CD4+ T cells show substantial proliferation whereas cells from Foxp3tm2Tch females do not proliferate

cellular
increased T cell apoptosis ( J:120636 )
• mice have a 4-fold increase in numbers of late apoptotic cells among EGFP+ CD4+ single positive thymocytes relative to controls
• EGFP+ T cells show more apoptosis than EGFP- T cells from the same mouse, or EGFP+ and EGFP-T cells from controls

endocrine/exocrine glands
decreased thymocyte number ( J:120636 )
• females have a lower percentage of EGFP+ CD4+ single positive thymocytes in the periphery compared to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory