Phenotypes Associated with This Genotype

Genotype
MGI:3707546

• Allelic Composition: Vldlr^tm1Her/Vldlr^tm1Her
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:55691 )

abnormal brain development ( J:55691 )

• cortical layering disrupted, layers not clearly separated and neurons were arranged in a radial fashion

abnormal cerebellum morphology ( J:55691 )

reduced cerebellar foliation ( J:55691 )

• less foliated than wild-type

small cerebellum ( J:55691 )

impaired synaptic plasticity ( J:79593 )

abnormal long-term potentiation ( J:79593 )

• while synaptic transmission and short term plasticity appeared normal in the CA1 region, LTP induction was impaired

reduced long-term potentiation ( J:79593 )

behavior/neurological

abnormal contextual conditioning behavior ( J:79593 )

• contextual fear-conditioned learning deficits

abnormal cued conditioning behavior ( J:79593 )

• cued conditioning was reduced when tested 24 hours following training, however it was normal when tested 1 hour following training

hyperactivity ( J:79593 )