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Phenotypes Associated with This Genotype
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens
• defect in the corneal stroma, which is filled with epithelial cells
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point
• the anterior pole of the lens is fused to the cornea
• failure of lens vesicle to separate from ectoderm
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium

Mouse Models of Human Disease
OMIM ID Ref(s)
Anterior Segment Mesenchymal Dysgenesis; ASMD 107250 J:40665

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory