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Phenotypes Associated with This Genotype
Genotype
MGI:3707320
Allelic
Composition
Pax6132-14Neu/Pax6+
Genetic
Background
C3.Cg-Pax6132-14Neu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6132-14Neu mutation (0 available); any Pax6 mutation (49 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens (J:40665)
• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens (J:40665)
• defect in the corneal stroma, which is filled with epithelial cells (J:40665)
• defect in the corneal stroma, which is filled with epithelial cells (J:40665)
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point (J:40665)
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point (J:40665)
• the anterior pole of the lens is fused to the cornea (J:40665)
• the anterior pole of the lens is fused to the cornea (J:40665)
• failure of lens vesicle to separate from ectoderm (J:40665)
• failure of lens vesicle to separate from ectoderm (J:40665)
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium (J:40665)
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium (J:40665)

Mouse Models of Human Disease
OMIM ID Ref(s)
Anterior Segment Mesenchymal Dysgenesis; ASMD 107250 J:40665


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory