Mouse Genome Informatics
ht
    Pax6132-14Neu/Pax6+
C3.Cg-Pax6132-14Neu
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Pax6132-14Neu/Pax6+ and Pax6132-14Neu/Pax6132-14Neu histological adult eye sections.

vision/eye
• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens
• defect in the corneal stroma, which is filled with epithelial cells
• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point
• the anterior pole of the lens is fused to the cornea
• failure of lens vesicle to separate from ectoderm
• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium

Mouse Models of Human Disease
OMIM IDRef(s)
Anterior Segment Mesenchymal Dysgenesis; ASMD 107250 J:40665