Phenotypes Associated with This Genotype

Genotype
MGI:3707320

• Allelic Composition: Pax6^132-14Neu/Pax6⁺
• Genetic Background: C3.Cg-Pax6^132-14Neu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pax6^132-14Neu/Pax6⁺ and Pax6^132-14Neu/Pax6^132-14Neu histological adult eye sections.

vision/eye

abnormal cornea morphology ( J:40665 )

abnormal corneal endothelium morphology ( J:40665 )

• fusion of the lens to the cornea is associated with a defect in the corneal stroma and endothelium, which is filled with epithelial cells continuous with those covering the conically projecting anterior surface of the lens

abnormal corneal stroma morphology ( J:40665 )

• defect in the corneal stroma, which is filled with epithelial cells

abnormal lens morphology ( J:40665 )

• in the lens, a plaque of multilayered epithelial cells and degenerated cortical fibers underlay the fusion point

fused cornea and lens ( J:40665 )

• the anterior pole of the lens is fused to the cornea

abnormal lens vesicle development ( J:40665 )

• failure of lens vesicle to separate from ectoderm

anterior polar cataract ( J:40665 )

• eyes in which the lens and cornea are separated display an anterior polar cataract and central corneal defect involving the stroma, Descemet's membrane, and endothelium