Phenotypes Associated with This Genotype

Genotype
MGI:3707223

• Allelic Composition: Dlg3^tm1Grnt/Y
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial learning ( J:120078 )

♂ • in Morris water maze test, with a visible, elevated platform, mutants' speed in reaching platform improves on day 2 and 3 of training whereas wild-type mice do not improve

♂ • in hidden platform paradigm, wild-type mice show improvement in performance over 5 days of training, while mutants do not

♂ • in a reversal platform protocol, mutants show a gradual improvement after 6 days, while wild-type learn the new platform position in the first block of training; retention of information on platform position is retained for 2 weeks, but by 8 weeks after training, mutants' performance is back to chance levels

♂ • in visible version of task, mutants use the approaching strategy, while wild-type use a less efficient self-orienting strategy; in the hidden (ie. hippocampus-dependent) version, mutants use a less efficient circling strategy, whereas wild-type use the approaching strategy, and with training switch to the direct finding strategy

abnormal locomotor activation ( J:120078 )

♂ • in assessment of motor abilities, mutants show an slightly altered locomotor phenotype measured by some differences in the rotarod, open field and elevated plus maze tests

nervous system

abnormal long-term potentiation ( J:120078 )

♂ • induction of LTP with conventional high-frequency protocol is similar in wild-type and mutant hippocampal slices; long-low-frequency train of synaptic stimulation produces a 2-fold increase in synaptic strength in mutant slices compared to only modest LTP in wild-type slices

♂ • pairing of single pulses of presynaptic fiber stimulation with single postsynaptic action potentials induces robust LTP in mutant cells but does not in wild-type cells