Phenotypes for Gna11 Gnaq Myl2 MGI:3706996 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gna11^tm1Soff/Gna11^tm1Soff Gnaq^tm2Soff/Gnaq^tm2Soff Myl2^tm1(cre)Krc/Myl2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna11^tm1Soff mutation (0 available); any Gna11 mutation (21 available)
Gnaq^tm2Soff mutation (0 available); any Gnaq mutation (24 available)
Myl2^tm1(cre)Krc mutation (2 available); any Myl2 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:77461 )

• about 75% die perinatally

cardiovascular system

heart hypoplasia ( J:77461 )

• pups that die perinatally exhibit varying degrees of myocardial hypoplasia

• however, mutants that survive to adulthood, appear normal and are fertile

decreased response of heart to induced stress ( J:77461 )

• homozygotes surviving to adulthood exhibit no ventricular hypertrophy in response to pressure-overload induced by aortic constriction, indicating a complete lack of a hypertrophic response

homeostasis/metabolism

decreased response of heart to induced stress ( J:77461 )

• homozygotes surviving to adulthood exhibit no ventricular hypertrophy in response to pressure-overload induced by aortic constriction, indicating a complete lack of a hypertrophic response

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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