Phenotypes Associated with This Genotype

Genotype
MGI:3706904

• Allelic Composition: Coro1a^tm1Achn/Coro1a^tm1Achn
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:111593 )

• CD4+ T cells display defective chemotactic migration in response to chemokines including CCL19, CXCL12, and CCL25 in a transwell migration assay

• when adoptively transferred, CD4+ cells that are Coro1a-deficient display defective homing to lymph nodes (~60% decrease) compared to wild-type CD4+ cells

decreased T cell number ( J:111593 )

• there is a paucity of T cells in spleen and lymph nodes of mutants

• naive splenic T cells are decreased in number

• naive T cells are reduced in blood and lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:111593 )

• cell number is decreased in the blood, spleen, and lymph nodes

• small reduction to CD4+ thymocytes is observed

decreased CD8-positive, alpha-beta T cell number ( J:111593 )

• cell number is decreased in the blood, spleen, and lymph nodes

• small reduction to CD4+ thymocytes is observed

decreased memory T cell number ( J:111593 )

• number of memory/effector T cells are reduced in blood and lymph nodes

hematopoietic system

abnormal leukocyte migration ( J:111593 )

• CD4+ T cells display defective chemotactic migration in response to chemokines including CCL19, CXCL12, and CCL25 in a transwell migration assay

• when adoptively transferred, CD4+ cells that are Coro1a-deficient display defective homing to lymph nodes (~60% decrease) compared to wild-type CD4+ cells

decreased T cell number ( J:111593 )

• there is a paucity of T cells in spleen and lymph nodes of mutants

• naive splenic T cells are decreased in number

• naive T cells are reduced in blood and lymph nodes

decreased CD4-positive, alpha-beta T cell number ( J:111593 )

• cell number is decreased in the blood, spleen, and lymph nodes

• small reduction to CD4+ thymocytes is observed

decreased CD8-positive, alpha-beta T cell number ( J:111593 )

• cell number is decreased in the blood, spleen, and lymph nodes

• small reduction to CD4+ thymocytes is observed

decreased memory T cell number ( J:111593 )

• number of memory/effector T cells are reduced in blood and lymph nodes

cellular

abnormal leukocyte migration ( J:111593 )

• CD4+ T cells display defective chemotactic migration in response to chemokines including CCL19, CXCL12, and CCL25 in a transwell migration assay

• when adoptively transferred, CD4+ cells that are Coro1a-deficient display defective homing to lymph nodes (~60% decrease) compared to wild-type CD4+ cells