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Phenotypes Associated with This Genotype
Genotype
MGI:3706813
Allelic
Composition
Foxo3tm1.1Rdp/Foxo3tm1.1Rdp
Foxo4tm1.1Rdp/Foxo4tm1.1Rdp
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Foxo4tm1.1Rdp mutation (0 available); any Foxo4 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• slightly increased incidence of ovarian stromal neoplasms (1/13 vs o wild-type)
• increased incidence of cystic teratoma (ovary) compared to wild-type (2/13 vs 0 wild-type)

nervous system
• females show increased pituitary adenoma (6/13 vs 0 wild-type)

respiratory system
• increased incidence of lung tumors (7/27 mice vs 1/6 wild-type)

endocrine/exocrine glands
• mice show increased incidence of Harderian gland tumors (4/27 vs 1/6 wild-type)
• slightly increased incidence of ovarian stromal neoplasms (1/13 vs o wild-type)
• increased incidence of cystic teratoma (ovary) compared to wild-type (2/13 vs 0 wild-type)
• females show increased pituitary adenoma (6/13 vs 0 wild-type)

neoplasm
• other unclassified tumors are seen with higher frequencies (3/27 vs 0 wild-type)
• mice show increased incidence of Harderian gland tumors (4/27 vs 1/6 wild-type)
• slightly increased incidence of ovarian stromal neoplasms (1/13 vs o wild-type)
• increased incidence of cystic teratoma (ovary) compared to wild-type (2/13 vs 0 wild-type)
• females show increased pituitary adenoma (6/13 vs 0 wild-type)
• increased incidence of lung tumors (7/27 mice vs 1/6 wild-type)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory