Phenotypes Associated with This Genotype

Genotype
MGI:3706791

• Allelic Composition: Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/0
• Genetic Background: involves: C57BL/10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:113713 )

• ratio of CD8+/CD4+ T cells increases from 0.5 in lymph nodes of control mice to 8 in transgenic mice

• positive selection of thymocytes bearing the transgenic TCR occurs, and leads to a bias towards CD8+ phenotype in mice of the H-2^b haplotype

increased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- cells increases from 2% in controls to 8-30% in transgenic thymus, along with a decrease in CD4+8- cells to 2% from 9% in controls

• in the lymph nodes, 70% of cells in transgenic mice are CD8+4- compared to 25% in controls

hematopoietic system

abnormal positive T cell selection ( J:113713 )

• ratio of CD8+/CD4+ T cells increases from 0.5 in lymph nodes of control mice to 8 in transgenic mice

• positive selection of thymocytes bearing the transgenic TCR occurs, and leads to a bias towards CD8+ phenotype in mice of the H-2^b haplotype

increased CD8-positive, alpha-beta T cell number ( J:113713 )

• proportion of CD8+4- cells increases from 2% in controls to 8-30% in transgenic thymus, along with a decrease in CD4+8- cells to 2% from 9% in controls

• in the lymph nodes, 70% of cells in transgenic mice are CD8+4- compared to 25% in controls