Phenotypes Associated with This Genotype

Genotype
MGI:3706705

• Allelic Composition: Cacna1a^tg-la/Cacna1a^Wb
• Genetic Background: involves: AKR/J * C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

dystonia ( J:119639 )

• mice having both mutant alleles are said to exhibit a severe ataxic/dystonic phenotype similar to that of homozygous wobbly mice, in contrast with the mild ataxia of wobbly heterozygotes

ataxia ( J:119639 )

• mice having both mutant alleles are said to exhibit a severe ataxic/dystonic phenotype similar to that of homozygous wobbly mice, in contrast with the mild ataxia of wobbly heterozygotes

impaired coordination ( J:119639 )

• in the hindlimb extension reflex test, mice with both mutant alleles exhibit spasmodic movements and flexion of the hindlimbs

• these compound mutant mice perform poorly in the inclined-plane test

• in the rotarod test, these compound mutant mice cannot maintain purchase on even a stationary rod

impaired fine motor coordination ( J:119639 )

• in the narrow-beam cross, mice with both mutant alleles are unable to cross a narrow beam toward a platform, indicating poor fine motor control

decreased grip strength ( J:119639 )

• the grip strength of mice with both mutant alleles is significantly weaker than that of wild-type controls

muscle

dystonia ( J:119639 )

• mice having both mutant alleles are said to exhibit a severe ataxic/dystonic phenotype similar to that of homozygous wobbly mice, in contrast with the mild ataxia of wobbly heterozygotes