Phenotypes Associated with This Genotype

Genotype
MGI:3706575

• Allelic Composition: Ager^tm1.1Hyam/Ager^tm1.1Hyam
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:116507 )

• after induction of diabetes with streptozotocin (STZ) injection, mice show decreased body weight compared to non-diabetic mutants

homeostasis/metabolism

abnormal blood homeostasis ( J:116507 )

• levels of circulating AGE (advanced glycation end products) are higher in diabetic mice than controls, regardless of Ager status

increased circulating glucose level ( J:116507 )

• after induction of diabetes with streptozotocin injection, mice have higher blood glucose levels than untreated controls

cardiovascular system

abnormal angiogenesis ( J:116507 )

• angiogenic response in an in vivo assay using implanted matrigel is similar in STZ-treated Ager-null mice and nondiabetic controls, whereas total cell number and smooth muscle cell number are significantly decreased in STZ-treated wild-type compared to untreated mice

cellular

decreased apoptosis ( J:116507 )

• number of apoptotic cells is decreased in STZ-treated and untreated Ager-null mice compared to STZ-treated wild-type controls

abnormal cell proliferation ( J:116507 )

• in STZ-treated mutants, cell proliferation is similar to untreated mutants or wild-type, whereas a significant decrease is observed in STZ-treated wild-type mice