Mouse Genome Informatics
tg
    Tg(Ins2-Nos2)40Okam/0
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• serum creatinine is much higher than in Ager-deficient transgenic mice at 8 months
• mice show sustained hyperglycemia (and display diabetes)
• mice have much higher urinary albumin/creatinine ratio than Ager-deficient transgenic mice or nontransgenic mice at 4 and 8 months

renal/urinary system
• mice have much higher urinary albumin/creatinine ratio than Ager-deficient transgenic mice or nontransgenic mice at 4 and 8 months
• compared to Ager-null transgenic mice, kidneys show changes associated with diabetic nephropathy such as increased S100 protein levels and AGE deposits
• accumulation of advanced glycation end product (AGE) deposits in renal glomeruli is greater than in Ager-deficient transgenics
• kidney weight composes a higher percentage of body weight compared to transgenic mice at 4 and 8 months

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:116040