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Phenotypes Associated with This Genotype
Genotype
MGI:3706545
Allelic
Composition
Tg(Ins2-Nos2)40Okam/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• serum creatinine is much higher than in Ager-deficient transgenic mice at 8 months
• mice show sustained hyperglycemia (and display diabetes)
• mice have much higher urinary albumin/creatinine ratio than Ager-deficient transgenic mice or nontransgenic mice at 4 and 8 months

renal/urinary system
• mice have much higher urinary albumin/creatinine ratio than Ager-deficient transgenic mice or nontransgenic mice at 4 and 8 months
• compared to Ager-null transgenic mice, kidneys show changes associated with diabetic nephropathy such as increased S100 protein levels and AGE deposits
• accumulation of advanced glycation end product (AGE) deposits in renal glomeruli is greater than in Ager-deficient transgenics
• kidney weight composes a higher percentage of body weight compared to transgenic mice at 4 and 8 months

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
J:116040


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory