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Phenotypes Associated with This Genotype
Genotype
MGI:3706543
Allelic
Composition		 Agertm1.1Hyam/Ager+
Tg(Ins2-Nos2)40Okam/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agertm1.1Hyam mutation (0 available); any Ager mutation (32 available)
Tg(Ins2-Nos2)40Okam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
hyperglycemia ( J:116040 )
• mice show sustained hyperglycemia (and display diabetes)

renal/urinary system
abnormal renal glomerulus morphology ( J:116040 )
• glomerular cell number is decreased compared to Ager-sufficient transgenic controls at 4 and 8 months
glomerulosclerosis ( J:116040 )
• progression of sclerosis is intermediate to Ager-sufficient or Ager-null transgenic mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory