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Phenotypes Associated with This Genotype
Genotype
MGI:3706341
Allelic
Composition		 Cdkn1atm1Tyj/Cdkn1atm1Tyj
Itgb1tm1Mll/Itgb1tm1Mll
Tg(Wap-cre)1Gsc/0
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1Tyj mutation (3 available); any Cdkn1a mutation (62 available)
Itgb1tm1Mll mutation (1 available); any Itgb1 mutation (58 available)
Tg(Wap-cre)1Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland growth during lactation ( J:99405 )
• mutants show a decrease in cell proliferation in mammary glands compared to wild-type, however they show a significant increase in cell proliferation compared to the conditional Itgb1 mutant glands, which represents a partial, 55%, reversion of the phenotype

integument
abnormal mammary gland growth during lactation ( J:99405 )
• mutants show a decrease in cell proliferation in mammary glands compared to wild-type, however they show a significant increase in cell proliferation compared to the conditional Itgb1 mutant glands, which represents a partial, 55%, reversion of the phenotype

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory